Researchers have discovered that misreading of therapeutic mRNAs by the cell's decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent 'off-target' immune responses to enable the safer design of future mRNA therapeutics.
Scientists have identified abnormal aggregates of a protein called TAF15 in the brains of individuals with early-onset dementia, known as frontotemporal dementia, where the cause was not previously known.
Galactic winds enable the exchange of matter between galaxies and their surroundings. In this way, they limit the growth of galaxies, that is, their star formation rate. Although this had already been observed in the local universe, an international research team has just revealed the existence of the phenomenon in galaxies which are more than 7 billion years old and actively forming stars, the category to which most galaxies belong. The team's findings thus show this is a universal process.
Researchers have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC). And in an early parallel study in humans, combining immunotherapy with dupilumab -- an Interleukin-4 (IL-4) receptor-blocking antibody widely used for treating allergies and asthma -- boosted patients' immune systems, with one out of the six experiencing significant tumor reduction.
Scientists reveal unprecedented insights into human limb development, including the many intricate processes that govern their formation.
Tropical cyclones are engines that use warm sea surfaces as fuel to move heat from the water to the upper atmosphere
Other key issues which cropped up during the discussion included a lack of support systems within the industry, how motherhood and family impact women’s science careers
In southern Germany just north of the Danube, there lies a large circular depression between the hilly surroundings: the Nördlinger Ries. Almost 15 million years ago, an asteroid struck this spot. Today, the impact crater is one of the most useful analogues for asteroid craters on early Mars. Studying the deposits of the former lake that formed in the crater is particularly informative. These deposits have been of great interest ever since NASA began exploring Martian craters for signs of water and life on Mars.
Researchers have provided detailed maps of how 144 common invasive plants species will react to 2° Celsius of climate change in the eastern U.S., as well as the role that garden centers currently play in seeding future invasions.
Sniffles, snorts and blows of runny noses are the hallmarks of cold and flu season -- and that increase in mucus is exactly what bacteria use to mount a coordinated attack on the immune system, according to a new study. The team found that the thicker the mucus, the better the bacteria are able to swarm. The findings could have implications for treatments that reduce the ability of bacteria to spread.
For some people, extreme stressors like psychiatric disorders or childhood neglect and abuse can lead to a range of health problems later in life, including depression, anxiety and cardiovascular disease. A new study identified genetic indicators that can predict another health problem, the decline of cognitive abilities, among people who have been affected by these extreme stressors.
A new tool will make it easier for clinicians and researchers to measure digital media addiction as new technologies emerge.
In some diseases, the underlying processes can start years before a diagnosis is made. A new study finds that people who later develop multiple sclerosis (MS) are more likely to have conditions like depression, constipation and urinary tract infections five years before their MS diagnosis than people who do not develop MS. The study also found that sexual problems and bladder infections, or cystitis, are more likely in people who later develop MS.
Scientists' debut 'reverse metabolomics,' a groundbreaking approach to advancing microbiome research. They use the technique to discover hundreds of new human molecules, and a new biomarker and therapeutic target for inflammatory bowel disease.
Research reveals strong social relationships make hyenas more likely to team up against lions, even when there's no obvious benefit.
Chemists have now come up with a way to make molecules known as acenes more stable, allowing them to synthesize acenes of varying lengths. Using their new approach, they were able to build molecules that emit red, orange, yellow, green, or blue light, which could make acenes easier to deploy in a variety of applications.
Pregnant women eating modern diets are missing key nutrients needed for them and their babies, and this could get worse with the move to plant-based foods. Scientists surveying more than 1,700 women found most were missing vitamins usually found in meat and dairy, including B12, B6 and D, folic acid and riboflavin which are essential for the development of fetuses in the womb.
A new report equips policymakers with the latest and most pivotal climate science research from the previous 18 months, synthesized to help inform negotiations at COP28 and policy implementation through 2024 and beyond.
A new organoid model of the dopaminergic system sheds lights on its intricate functionality and potential implications for Parkinson's disease. The model replicates the dopaminergic system's structure, connectivity, and functionality.
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