Science Daily

Abnormal blood flow in the aorta is linked to inflammation and breakdown of the vessel wall in conditions where the aorta is dilated. The findings can contribute to better diagnosis and open up new ways to assess the risk of serious and usually fatal complications, such as rupture of the aorta.

Boys are good at math, girls not so much? A study has analyzed the social mechanisms that contribute to the gender gap in math confidence. While peer comparisons seem to play a crucial role for boys, girls' subjective evaluations are more likely to be based on objective performance.

Why does Hepatitis E become chronic in some patients, and why do medications not work? To find out, an international research team led by scientists from Bochum observed a patient with chronic Hepatitis E infection over a year. Repeated sequencing of the virus RNA showed that the virus incorporated various parts of the host's messenger RNA into its genome. This resulted in a replication advantage, which may have contributed to the infection becoming chronic.

A study has revealed that fine particulate matter from 1980 to 2020 was associated with approximately 135 million premature deaths globally.

People with an optimistic outlook on the future are less likely to be severe procrastinators, according to new research. While procrastinators often admonish themselves for their 'bad habit,' it turns out that their worries for the future are more to blame. Through a survey of nearly 300 young people, researchers found that those who had a positive view about their stress levels decreasing in the future, compared to the past or present, were less likely to experience severe procrastination. Views on personal well-being didn't appear to have an effect. Improving people's outlook and readiness for the future could help them overcome procrastination and achieve a less stressful lifestyle.

Scientists have improved a gene-editing technology that is now capable of inserting or substituting entire genes in the genome in human cells efficiently enough to be potentially useful for therapeutic applications. The advance could one day help researchers develop a single gene therapy for diseases such as cystic fibrosis that are caused by one of hundreds or thousands of different mutations in a gene. Using this new approach, they would insert a healthy copy of the gene at its native location in the genome, rather than having to create a different gene therapy to correct each mutation using other gene-editing approaches that make smaller edits.

How do pathogens invade the lungs? Using human lung microtissues, a team has uncovered the strategy used by a dangerous pathogen. The bacterium targets specific lung cells and has developed a sophisticated strategy to break through the lungs' line of defense.

Astrophysicists calculate the likelihood that Earth was exposed to cold, harsh interstellar clouds, a phenomenon not previously considered in geologic climate models.

Efforts to tackle false information through fact-checking or media literacy initiatives increases the public's skepticism toward 'fake news'. However, they also breed distrust in genuine, fact-based news sources, a new study using online survey experiments in the US, Poland and Hong Kong shows.

Academics are often accused of 'splitting hairs', but a team has now devised a machine to do just that. We all have a bad hair day from time to time, and split ends are a common problem. However, the science behind this kind of hair damage is poorly understood, which is why scientists are investigating this knotty problem.

People who eat a healthy, sustainable diet may substantially lower their risk of premature death in addition to their environmental impact, according to a new study. This large study directly evaluates the impacts of adherence to recommendations in the landmark 2019 EAT-Lancet report. The researchers have named the dietary pattern outlined in the report -- which emphasizes a variety of minimally processed plant foods but allows for modest consumption of meat and dairy foods -- the Planetary Health Diet (PHD).

A clinical trial on a two-drug therapy for methamphetamine use disorder reduced use of the highly addictive drug for up to 12 weeks after initiation of treatment. Participants in the ADAPT-2 clinical trial who received a combination of injectable naltrexone plus extended-release oral bupropion (NTX+BUPN) had a 27% increase in methamphetamine-negative urine tests, indicating reduced usage. By contrast, the placebo group had an 11% increase in negative tests. To date there is no FDA-approved medication for it.

When scientists transplanted the gut microbes of aged mice into young 'germ-free' mice -- raised to have no gut microbes of their own -- the recipient mice experienced an increase in inflammation that parallels inflammatory processes associated with aging in humans. Young germ-free mice transplanted with microbes from other young mice had no such increase.

An international research team has discovered the oldest known marine plant using a novel genetic clock. This 1400-year-old seagrass clone from the Baltic Sea dates back to the Migration Period. The research project is a significant step towards better understanding and protecting marine ecosystems.

The platitude that failure leads to success may be both inaccurate and damaging to society, according to new research.

A new study suggests that the immune response of lung endothelial cells, which line the blood vessels, is too low during the early stage of COVID-19 infection as demonstrated in a preclinical model. Additionally, the researchers analyzed all genes expressed in purified endothelial cells, which had never been done before.

Immune activation in a pregnant woman can occur in response to metabolic diseases like obesity, infections in pregnancy, exposure to pollution and environmental toxins, or even stress and can have negative effects on fetal brain immune cells (microglia). It's not possible to monitor microglia within the fetal brain, but new research indicates that macrophages in the placenta can act as an indicator of these cells' health.

After women go through menopause, their risk of heart disease increases dramatically. Researchers studied whether beetroot juice, which is rich in nitrate, can improve how blood vessels function. The results showed that daily consumption of beetroot juice by postmenopausal women may improve blood vessel function enough to reduce future heart disease risk.

Having explored how the heart is formed in utero, a researcher is reporting how cells and molecules act during that early formation and what might cause the heart disease called left ventricular non-compaction or spongy heart, for which patients often require heart transplants.

A new study has found that patients diagnosed with schizophrenia or another psychotic disorder are three times more likely to have Bartonella DNA in their blood than adults without these disorders. The work further supports the idea that pathogens -- particularly vector-borne pathogens -- could play a role in mental illness.