Preliminary clinical data for glioblastoma multiforme patients enrolled in a Phase 1 clinical trial demonstrated that 92 percent of evaluable patients treated with INB-200 exceeded a median progression-free survival of seven months with concomitant temozolomide chemotherapy. The median follow-up was 11.7 months. This survival data along with radiographic improvements are indicative of positive treatment effects, which highlights the potential of IN8bio's genetically modified, chemotherapy-resistant gamma-delta T cells as a potential first-in-class therapy for patients with newly diagnosed glioblastoma.
Australia's ski industry is at risk of major disruptions and shorter seasons if the current level of climate pollution continues, according to new modelling. The report found the average ski season across all resorts in Australia will be 44 days shorter by 2050 under a mid-greenhouse gas emissions scenario and 55 days shorter under a high-emissions scenario.
The role that Epstein-Barr Virus (EBV) plays in the development of Multiple Sclerosis may be caused a higher level of cross-reactivity, where the body's immune system binds to the wrong target, than previously thought.
The annual killifish lives in regions with extreme drought. A research group now reports that the early embryogenesis of killifish diverges from that of other species. Unlike other fish, their body structure is not predetermined from the outset. This could enable the species to survive dry periods unscathed.
By ditching 'pop psychology myths' about habits, we can better understand our habits and take more effective action, according to researchers.
Some cancer drugs cause severe side effects because they are not working accurately enough. Biochemists have now discovered why.
Chemists have developed a strategy using disulfide-containing small molecules to facilitate the reversible control and delivery of ribonucleic acid (RNA). A research team has developed a method that takes advantage of a chemical process called post-synthetic RNA acylation chemistry, and combined it with dynamic disulfide exchange reaction for RNA delivery and reversible control. This method provides a way to mask the RNA molecule, and researchers can potentially regulate its activity and delivery until it reaches its target site within the cell.
A breakthrough study changes the way we understand cyanobacteria, which are essential for the sustenance of life. The study shows that these organisms do not operate in isolation, but rather physically interact through membrane-nanotubes, which function as exchange bridges between cells.
A new material may be the key to quickly flag damaged infrastructure. This material offers a way to reduce the manpower required to regularly monitor structures that undergo daily use such as bridges. Compared to previous methods, this environmentally friendly material boasts the ability to operate without a power supply, and store information about previous incidents of mechanical stress. The application of this mechanoluminescent material is expected to make it easier and less costly to assess the safety of structures we may use in our everyday lives.
A research team has developed a liquid metal-based electronic logic device that mimics the intelligent prey-capture mechanism of Venus flytraps. Exhibiting memory and counting properties, the device can intelligently respond to various stimulus sequences without the need for additional electronic components. The intelligent strategies and logic mechanisms in the device provide a fresh perspective on understanding 'intelligence' in nature and offer inspiration for the development of 'embodied intelligence'.
Little is yet known about the health effects of nanoparticles on pregnancy. An interdisciplinary team is currently analyzing the risks for babies in the womb. Using a lab model, the researchers were able to determine that certain nanoparticles impair the release of chemical messengers in the placenta and thus the formation of blood vessels.
Women with excess weight at age 14 or 31 may have increased ischemic (clot caused) stroke risk before age 55. The same ischemic stroke risk was not found in men. Losing excess weight after adolescence may not eliminate the stroke risk.
In a major advance for the treatment of the deadly brain cancer glioblastoma, scientists used ultrasound technology to penetrate the blood-brain barrier and provide a small dose of a chemotherapy and immunotherapy drug cocktail. The study found that this treatment boosted the immune system's recognition of the cancer cells and could lead to a new treatment approach.
A searchable database is now ready to help study Alzheimer's disease. Neuroscience and biomedical informatics researchers have created the comprehensive, user-friendly repository.
New research led by Lia Siegelman, a physical oceanographer at UC San Diego's Scripps Institution of Oceanography, shows that the roiling storms at the planet Jupiter's polar regions are powered by processes known to physicists studying Earth's oceans and atmosphere. The geophysical commonalities spanning the 452 million miles between the two planets could even help facilitate an improved understanding of those processes on Earth.
A lifesaving package including early detection and bundled treatment for women who have heavy bleeding during childbirth has been found to incur minimal additional cost according to new analysis from 78 hospitals around the world.
A new study has revealed the hidden emotional challenges patients go through following tooth loss. Patients highlight feelings of self-consciousness, shame or fear as well as physical sensations such as pain and sensitivity and worries about how tooth loss might impact their life.
Researchers use lessons from nanomedicine and digital twin technologies to address food insecurity and climate change.
Advanced technologies enable the controlled release of medicine to specific cells in the body. Scientists argue these same technologies must be applied to agriculture if growers are to meet increasing global food demands.
Innate immune cells including macrophages and neutrophils have unique properties that allows them to quickly accumulate in large numbers at the site of infection or injury. A new study establishes that macrophage in the adult ischemic muscle induce a phenotype switch into mural cells to support restoration of functional blood flow and thereby promote healing. This finding pinpoints macrophages as a potential target for therapeutically enhancing vascular integrity and healing of ischemic injuries.
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