More than 65,000 men fall ill with prostate cancer each year in Germany. Twelve thousand of them develop a treatment-resistant form which eventually ends in death. Now, a team of researchers has developed an active substance that might in future represent a new treatment option. This substance, known as KMI169, targets an enzyme that plays an important role in the development of prostate cancer.
A study has found that green ammonia could be used to fulfill the fuel demands of over 60% of global shipping by targeting just the top 10 regional fuel ports. Researchers looked at the production costs of ammonia which are similar to very low sulphur fuels, and concluded that the fuel could be a viable option to help decarbonize international shipping by 2050.
Chemists have presented a new approach in which a single carbon atom is inserted into the carbon skeleton of cyclic compounds in order to adjust the ring size. The method could be relevant, for example, for the production of active ingredients in new pharmaceutical products.
Models used by scientists to predict how epidemics will spread have a major flaw since they do not take into account the structure of the networks underlying transmission.
Daylight Saving Time (DST) might be influencing our internet habits, according to new research.
A high-sugar diet is bad news for humans, leading to diabetes, obesity and even cancer. Yet fruit bats survive and even thrive by eating up to twice their body weight in sugary fruit every day.
An experimental study has shown that a type of skin bacterium can efficiently be engineered to produce a protein to regulate sebum production. This application could treat acne without compromising the homeostasis of the entire skin microbiome.
As the potter works the spinning wheel, the friction between their hands and the soft clay helps them shape it into all kinds of forms and creations. In a fascinating parallel, sea squirt oocytes (immature egg cells) harness friction within various compartments in their interior to undergo developmental changes after conception.
Analysis of iron meteorites from the earliest years of the solar system indicate that the planetary 'seeds' that ultimately formed Earth contained water.
Brown fat cells convert energy into heat -- a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers have now identified the protein EPAC1 as a new pharmacological target to increase brown fat mass and activity. The long-term aim is to find medicines that support weight loss.
Decisions on treatment for leukemia patients are based, among other things, on a series of certain genetic features of the disease. IT specialists and physicians have now shown how a method based on artificial intelligence can be used to predict various genetic features on the basis of high-resolution microscopic images of bone marrow smears.
Researchers have revealed a reason why endocrine resistance develops in breast cancers and how to potentially treat it in patients.
A study has used the power of machine learning to overcome a key challenge affecting quantum devices. For the first time, the findings reveal a way to close the 'reality gap': the difference between predicted and observed behavior from quantum devices.
Robots and autonomous vehicles can use 3D point clouds from LiDAR sensors and camera images to perform 3D object detection. However, current techniques that combine both types of data struggle to accurately detect small objects. Now, researchers have developed DPPFA Net, an innovative network that overcomes challenges related to occlusion and noise introduced by adverse weather. Their findings will pave the way for more perceptive and capable autonomous systems.
Felspar dust in the air can create clouds. The feldspar particles act as nucleation sites to which water molecules can attach extremely efficiently. Why this is the case has remained a mystery for a long time. Scientists have now studied feldspar using a special atoimic force microscope and managed to explain this remarkable property of feldspar on an atomic level. The atomic structure is just right to create a layer of OH-groups which in turn can connect to water molecules perfectly.
Researchers have carried out complex genetic analyses of hundreds of pigs and humans to identify differences and similarities. This new knowledge can be used to ensure healthier pigs for farmers and can help the pharmaceutical industry breed better laboratory pigs for testing new medicines.
Researchers are unraveling the workings of Group B Strep (GBS) infections in pregnant women, which could someday lead to a life-saving vaccine.
An international team of scientists has used a novel 500-year dataset to frame a 'restorative' pathway through which humanity can avoid the worst ecological and social outcomes of climate change.
Researchers have made a groundbreaking discovery regarding the origins of non-meteoric water in natural spa waters located in central Japan. Based on numerical modeling, their results suggest that this water has been confined within the lithosphere for an extensive period of 1.5-5 million years. They identified three primary sources for this ancient water: the Philippine Sea Plate, the Pacific Plate, and ancient seafloor sediments, particularly in the Niigata and southwest Gunma regions.
From a wartime spread of antimicrobial resistant disease in Ukraine, to superbugs in China causing 'white lung' pneumonia in children, 2023 brought no shortage of new evidence that antimicrobial resistance (AMR) continues to be a pressing problem globally, and this pattern shows no sign of abating in 2024 unless a radical shift occurs. To truly tackle the issue of AMR, researchers with the Global Strategy Lab (GSL) argue it needs to be understood as a socio-ecological challenge that accepts AMR as a phenomenon stemming from natural evolutionary processes. In other words, the war on bugs can't be won; what's needed is a major change in how people live with it.
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