Researchers have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working. Their study also explains why the cancer cells are resistant and how this resistance can be overcome: through concomitant pharmacotherapy or genetically improved CAR T-cells.
Researchers examined the developmental processes and reproduction-related behavior of 8 of the 11 families of Dermaptera (earwigs) in detail and compared with those reported in previous studies. The results confirmed that Dermaptera is a polyneopteran order, and the features such as caudal forceps and elaborate maternal care for eggs and young larvae emerged in parallel within the order during evolution.
A 3D-printed 'brain phantom' has been developed, which is modeled on the structure of brain fibers and can be imaged using a special variant of magnetic resonance imaging (dMRI). The scientific team has now shown in a study, these brain models can be used to advance research into neurodegenerative diseases such as Alzheimer's, Parkinson's and multiple sclerosis.
Finding viable alternatives to traditional petroleum-based plastics and microplastics has never been more important. New research shows that their plant-based polymers biodegrade -- even at the microplastic level -- in under seven months.
Scientists have explored the puzzling world of rays that lived 150 million years ago and discovered a previously hidden diversity -- including a new ray species. This study significantly expands the understanding of these ancient cartilaginous fish and provides further insights into a past marine ecosystem.
Following injury, plants release terpenoids to enhance their defenses. Researchers studying terpenoid-enriched essential oils (EOs) have found that rose EO (REO) can stimulate defense genes in tomato leaves. Furthermore, REO attracts herbivores that protect the plant from the moth species, Spodoptera litura, and Tetranychus urticae, a mite pest. This suggests that applying REO could be a sustainable approach to pest management in organic farming.
A researcher has developed a new model that provides a holistic view on how our brain manages to learn quickly and forms stable, long-lasting memories. Their study sheds light on the crucial role of interactions among neighboring contact sites of nerve cells for brain plasticity -- the brain's ability to adapt to new experiences.
A challenge to space scientists to better understand our hazardous near-Earth space environment has been set in a new study.
The oldest Scandinavian bedrock was 'born' in Greenland, according to a new geological study. The study helps us understand the origin of continents and why Earth is the only planet in our solar system with life.
Using novel genetic and genomic tools, researchers have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases. The study represents a step forward in understanding immune cell regulation and its impact on disease progression.
Aging may be less about specific 'aging genes' and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers. A decline in the expression of long genes with age has been observed in a wide range of animals, from worms to humans, in various human cell and tissue types, and also in individuals with neurodegenerative disease. Mouse experiments show that the phenomenon can be mitigated via known anti-aging factors, including dietary restriction.
Scientists have uncovered the fossilized skull of a 270-million-year-old ancient amphibian ancestor in the collection of the Smithsonian's National Museum of Natural History. The team of researchers described the fossil as a new species of proto-amphibian, which they named Kermitops gratus in honor of the iconic Muppet, Kermit the Frog.
The first study of humpback whale entanglements in B.C. aquaculture facilities found eight over 13 years, with the curiosity of young whales a potential contributing factor.
A group of coastal Alaska Native tribes in 2016 began monitoring shellfish, a traditional harvest, for deadly biotoxins because the state only tests commercial harvests. The program fills an essential gap in public health protection and has found success, with 17 tribes now in the testing network. Securing stable, long-term funding and improving public outreach could improve outcomes even further, a new study reports.
A research team has developed an n-channel diamond MOSFET (metal-oxide-semiconductor field-effect transistor). The developed n-channel diamond MOSFET provides a key step toward CMOS (complementary metal-oxide-semiconductor: one of the most popular technologies in the computer chip) integrated circuits for harsh-environment- applications as well as the development of diamond power electronics.
What maintains stability within an ecosystem and prevents a single best competitor from displacing other species from a community? Does ecosystem stability depend upon the presence of a wide variety of species, as early ecologists believed, or does diversity do the exact opposite, and lead to instability, as modern theory predicts? A new study suggests an answer to this question that has been a subject of debate among ecologists for half a century.
New research finds a direct communication path between the lungs and the brain which may change the way we treat respiratory infections and chronic conditions. The lungs are using the same sensors and neurons in the pain pathway to let the brain know there's an infection. The brain then prompts the symptoms associated with sickness. Findings indicate we may have to treat the nervous system as well as the infection.
A research consortium made a recent discovery that the natural molecule trigonelline present in coffee, fenugreek, and also in the human body, can help to improve muscle health and function.
The dust of comets fills the space between the planets, collectively called the zodiacal cloud. Still, severe breakdown has reduced that dust in size so much that it now scatters sunlight efficiently, causing the faint glow in the night sky known as the 'zodiacal light.' It was long thought that high-speed collisions pulverized the comet ejecta, but now a team of researchers reports that heat is to blame.
A research team has begun translating the complex molecular language of petunias. Their grammar and vocabulary are well hidden, however, within the countless proteins and other compounds that fill floral cells. Being rooted to the ground, plants can't run away from insects, pathogens or other threats to their survival. But plant scientists have long known that they do send warnings to each other via scent chemicals called volatile organic compounds.
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