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One-two punch treatment delivers blood cancer knockout

01/05/2024
A novel combination of two cancer drugs has shown great potential as a future treatment for patients with acute myeloid leukaemia (AML), one of the most common types of blood cancers. A new study has revealed the combination of two existing drugs eradicated AML cancer cells in lab-based tests. The discovery could soon lead to clinical trials.

Revised dating of the Liujiang skeleton renews understanding of human occupation of China

01/05/2024
Researchers have provided new age estimates and revised provenance information for the Liujiang human fossils, shedding light on the presence of Homo sapiens in the region. Using advanced dating techniques including U-series dating on human fossils, and radiocarbon and optically stimulated luminescence dating on fossil-bearing sediments, the study revealed new ages ranging from approximately 33,000 to 23,000 years ago. Previously, studies had reported ages of up to 227,000 years of age for the skeleton.

Time zones and tiredness strongly influence NBA results, study of 25,000 matches shows

01/05/2024
The body clock has a significant impact on the performance of NBA players. Data shows vastly better win ratio for home teams from the Western Time Zone Area (PDT) when playing an EDT team, compared to vice versa.

New Japanese lily species identified, 1st addition to sukashiyuri group in 110 years

01/05/2024
For the first time since 1914, a new species of the Japanese lily known as sukashiyuri has been identified. A research team analyzed the morphology and DNA of these lilies and has revised the conventional classification from four taxonomic groups to eight.

Discovery of an atypical heat shock factor, HSF5, involved in meiotic mechanisms: Implications for male infertility

01/05/2024
Researchers have identified a novel Heat Shock Factor (HSF), designated as HSF5, which plays a crucial role in the completion of meiosis and the activation of genes essential for sperm formation. This discovery provides valuable insights into underlying causes of spermatogenic failure, the major contributor to male infertility. Furthermore, unlike other typical Heat Shock Factors, which primarily regulate gene expression in response to stress, such as heat shock, HSF5 plays a specific role in male germ production during meiosis under non-stress conditions.

A blood test for stroke risk? Biomarker for risk of future cerebrovascular disease

01/05/2024
A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new study.

Brief anger may impair blood vessel function

01/05/2024
When adults became angry after remembering past experiences, the function of cells lining the blood vessels was negatively impaired, which may restrict blood flow, according to a new study. Previous research has found that this may increase the risk of heart disease and stroke. In this study, episodes of anxiety and sadness did not trigger the same change in functioning of the blood vessel lining.

Improved AI process could better predict water supplies

01/05/2024
A new computer model uses a better artificial intelligence process to measure snow and water availability more accurately across vast distances in the West, information that could someday be used to better predict water availability for farmers and others. The researchers predict water availability from areas in the West where snow amounts aren't being physically measured.

Novel genetic plant regeneration approach without the application of phytohormones

01/05/2024
Conventional plant regeneration approaches by cell culture require the external application of plant growth regulators, including hormones. However, optimizing culture conditions can be laborious. Now, researchers have developed a novel plant regeneration system that omits the need for hormone application by genetically regulating the expression of genes that control plant cell differentiation. Their work holds significant potential in the development of genetically modified plants in a simpler and cost-effective manner.

Activity in a room stirs up nanoparticles left over from consumer sprays

01/05/2024
Common household products containing nanoparticles -- grains of engineered material so miniscule they are invisible to the eye -- could be contributing to a new form of indoor air pollution, according to a new study.

An electrifying discovery may help doctors deliver more effective gene therapies

01/05/2024
In an effort to improve delivery of costly medical treatments, a team of researchers in electrical engineering has developed a stimulating method that could make the human body more receptive to certain gene therapies.

Astronomers share climate-friendly meeting solutions

01/05/2024
Carbon emissions associated with air travel to professional conferences make up a sizable fraction of the emissions produced by researchers in academia.

Breakthrough in complex pain management

01/05/2024
Complex Regional Pain Syndrome (CRPS) is a chronic and debilitating pain disorder, typically considered lifelong with limited treatment options. Now, groundbreaking research finds that early detection and effective treatment can lead to significant recovery within 18 months, offering hope to millions of people worldwide.

Scientists show ancient village adapted to drought, rising seas

01/05/2024
Researchers have unveiled evidence for ancient human resilience to climate change in the Eastern Mediterranean.

Is it time to retire the best-before date?

01/05/2024
The inventors of a suite of tests that enable food packages to signal if their contents are contaminated are working to bring producers and regulators together to get their inventions into commercial products, with the goal of preventing illness and reducing food waste.

Student links worm behavior to brain disease

01/05/2024
An undergraduate student turns her honor's thesis into a peer-reviewed publication on schizophrenia research.

Uncovering the secret of long-lived stem cells

01/05/2024
Researchers have discovered that the enzyme cyclophilin A, which is produced in large amounts in hematopoietic stem cells, is key for these cells to retain their regenerative potential and avert the effects of aging via an unexpected mechanism.

Missing link in species conservation: Pharmacists, chemists could turn tide on plant, animal extinction

01/05/2024
As the world faces the loss of a staggering number of species of animals and plants to endangerment and extinction, one scientist has an urgent message: Chemists and pharmacists should be key players in species conservation efforts.

Researchers develop an AI model to reduce uncertainty in evapotranspiration prediction

01/05/2024
Evapotranspiration (ET) includes evaporation from soil and open water pools such as lakes, rivers, and ponds, as well as transpiration from plant leaves. The difference between precipitation and ET indicates the water balance available for societal needs, including agricultural and industrial production. However, measuring ET is challenging. A new study presents a computer model that uses artificial intelligence (AI) for ET prediction based on remote sensing estimates.

Climate change and mercury pollution stressed plants for millions of years

01/05/2024
The link between massive flood basalt volcanism and the end-Triassic (201 million years ago) mass-extinction is commonly accepted. However, exactly how volcanism led to the collapse of ecosystems and the extinction of entire families of organisms is difficult to establish. Extreme climate change from the release of carbon dioxide, degradation of the ozone layer due to the injection of damaging chemicals, and the emissions of toxic pollutants, are all seen as contributing factors. One toxic element stands out: mercury.

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